Evolution of tubulointerstitial fibrosis in experimental renal infection and scarring.
نویسندگان
چکیده
منابع مشابه
Renal tubulointerstitial fibrosis: common but never simple.
Regardless of etiology, all patients with chronic renal disease show a progressive decline in renal function with time. Fibrosis, so-called scarring, is a key cause of this pathophysiology. Fibrosis involves an excess accumulation of extracellular matrix (primarily composed of collagen) and usually results in loss of function when normal tissue is replaced with scar tissue. While recent major a...
متن کاملMyofibroblast phenotypes expression in experimental renal scarring.
BACKGROUND Myofibroblasts have been implicated in the pathogenesis of wound healing and tissue fibrosis. A role has also been put forward for these cells in the development of experimental and clinical renal scarring. SUBJECTS AND METHODS We examined the expression of myofibroblast phenotypes by immunohistochemistry, relying on an avidin-biotin-peroxidase method, during the course of renal sc...
متن کاملCRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis.
BACKGROUND Cellular retinol-binding protein I (CRBP-I), a member of the intracellular lipid-binding protein (iLBP) superfamily, is a specific marker of quiescent stellate cells in the healthy human liver. In the diseased fibrotic/cirrhotic liver, portal and septal myofibroblasts acquire CRBP-I expression, while activated hepatic stellate cells maintain their CRBP-I expression. Here, we investig...
متن کاملmiR-200b Precursor Can Ameliorate Renal Tubulointerstitial Fibrosis
Members of the miR-200 family of micro RNAs (miRNAs) have been shown to inhibit epithelial-mesenchymal transition (EMT). EMT of tubular epithelial cells is the mechanism by which renal fibroblasts are generated. Here we show that miR-200 family members inhibit transforming growth factor-beta (TGF-beta)-induced EMT of tubular cells. Unilateral ureter obstruction (UUO) is a common model of EMT of...
متن کاملThe Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis
Renal tubulointerstitial fibrosis (TIF) is the final pathway of various renal injuries that result in chronic kidney disease. The mammalian Hippo-Salvador signaling pathway has been implicated in the regulation of cell proliferation, cell death, tissue regeneration, and tumorigenesis. Here, we report that the Hippo-Salvador pathway plays a role in disease development in patients with TIF and in...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1998
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v94632